Constraint-based network model of pathogen-immune system interactions.

ABSTRACT: Pathogenic bacteria such as Bordetella bronchiseptica modulate host immune responses to enable their establishment and persistence; however, the immune response is generally successful in clearing these bacteria. Here, we model the dynamic outcome of the interplay between host immune components and B. bronchiseptica virulence factors. The model extends our previously published interaction network of B. bronchiseptica and includes the existing experimental information on the relative timing of IL10 and IFNgamma activation in the form of qualitative inequalities. The current model improves the previous one in two directions: (i) by augmenting the network with new nodes with specific function in T helper cell differentiation and effector mechanisms and (ii) by using a dynamic approach that al

SUBMITTER: Thakar J 

PROVIDER: S-EPMC2696137 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature