Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS.

ABSTRACT:

Objective

Angiopoietin-2 (Ang-2) is a potent regulator of vascular permeability and inflammation in acute lung injury and acute respiratory distress syndrome (ARDS). Genetic variants in the Ang-2 gene may lead to altered activities of Ang-2 (or ANGPT2) gene. The aim of this study was to assess if genetic variants of Ang-2 are associated with the risk of ARDS.

Design

Unmatched, case-control study nested within a prospectively enrolled cohort.

Setting

Intensive care units (ICU) of an academic medical center.

Patients

About 1,529 critically ill patients with risk factors for ARDS consecutively admitted to the ICUs from 1999 to 2006. Cases were 449 patients who developed ARDS and controls were 1,080 subjects who did not developed ARDS.

Intervention

None.

SUBMITTER: Su L 

PROVIDER: S-EPMC2696283 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature