Stoned B mediates sorting of integral synaptic vesicle proteins.

ABSTRACT: A continuous supply of fusion-competent synaptic vesicles is essential for sustainable neurotransmission. Drosophila mutations of the dicistronic stoned locus disrupt normal vesicle cycling and cause functional deficits in synaptic transmission. Although both Stoned A and B proteins putatively participate in reconstituting synaptic vesicles, their precise function is still unclear. Here we investigate the effects of progressive depletion of Stoned B protein (STNB) on the release properties of neuromuscular synapses using a novel set of synthetic stnB hypomorphic alleles. Decreasing neuronal STNB expression to < or =35% of wild-type level causes a strong reduction in excitatory junctional current amplitude at low stimulation frequencies and a marked slowing in synaptic depression during hig

SUBMITTER: Mohrmann R 

PROVIDER: S-EPMC2696304 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature