TNF-induced MAP kinase activation oscillates in time.

ABSTRACT: Oscillations in the activation of multiple signaling pathways have never been shown before. Our results presented in the previous accompanying paper showed that TNF induces highly dynamic oscillations in mRNA production in approximately 13% of the mouse genome. Here, we further analyze the TNF time-series microarray data and find that multiple signaling components downstream of the TNF receptor undergo oscillations. Prior studies implicate IkappaBalpha and A-20 as the only oscillatory components in the TNF signaling cascade. We find however, that other components, such as TRAF1, displayed oscillations. This suggested the possibility that all signaling output from the TNF receptor may be oscillatory in nature. Indeed, we show that TNF triggers oscillations in the phosphorylation of three MA

SUBMITTER: Iqbal J 

PROVIDER: S-EPMC2696359 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature