Chromosomal imbalance in the progression of high-risk non-muscle invasive bladder cancer.

ABSTRACT:

Background

Non-muscle invasive bladder neoplasms with invasion of the lamina propria (stage T1) or high grade of dysplasia are at "high risk" of progression to life-threatening cancer. However, the individual course is difficult to predict. Chromosomal instability (CI) is associated with high tumor stage and grade, and possibly with the risk of progression.

Methods

To investigate the relationship between CI and subsequent disease progression, we performed a case-control-study of 125 patients with "high-risk" non-muscle invasive bladder neoplasms, 67 with later disease progression, and 58 with no progression. Selection criteria were conservative (non-radical) resections and full prospective clinical follow-up (> 5 years). We investigated primary lesions in 59, and recurrent l

SUBMITTER: Zieger K 

PROVIDER: S-EPMC2696467 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature