Cu(I)-catalyzed diamination of disubstituted terminal olefins: an approach to potent NK1 antagonist.

ABSTRACT: This paper describes a diamination process using di-tert-butyldiaziridinone as nitrogen source and CuCl as catalyst. A wide variety of disubstituted terminal olefins can be efficiently diaminated in good yields under mild condition. This diamination process was used to synthesize potent NK(1) antagonist Sch 425078.

SUBMITTER: Wen Y 

PROVIDER: S-EPMC2696623 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature