A role for gamma/delta T cells in a mouse model of fracture healing.

ABSTRACT:

Objective

Fractures can initiate an immune response that disturbs osteoblastic and osteoclastic cellular homeostasis through cytokine production and release. The aim of our study was to investigate gamma/delta T cells, innate lymphocytes known to be involved in tissue repair, as potential cellular components of the osteoimmune system's response to an in vivo model of bone injury. The absence of such cells or their effector cytokines influences the fate of other responder cells in proliferation, differentiation, matrix production, and ultimate callus formation.

Methods

Tibia fractures were created in 60 gamma/delta T cell-deficient mice (also called delta T cell receptor [TCR]-knockout mice) and 60 control C57BL/6 mice. Analysis included radiographs, basic histology, mechanic

SUBMITTER: Colburn NT 

PROVIDER: S-EPMC2697263 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature