Bif-1/endophilin B1: a candidate for crescent driving force in autophagy.

ABSTRACT: Autophagy is an intracellular bulk degradation system that plays a vital role in maintaining cellular homeostasis. This degradation process involves dynamic membrane rearrangements resulting in the formation of double-membraned autophagosomes. However, the driving force for generating curvature and deformation of isolation membranes remains a mystery. Bax-interacting factor 1 (Bif-1), also known as SH3GLB1 or Endophilin B1, was originally discovered as a Bax-binding protein. Bif-1 contains an amino-terminal N-BAR (Bin-Amphiphysin-Rvs) domain and a carboxy-terminal SH3 (Src-homology 3) domain and shows membrane binding and bending activities. It has been shown that Beclin1 is involved in the nucleation of autophagosomal membranes through an unknown mechanism. It is interesting that, Bif-1 f

SUBMITTER: Takahashi Y 

PROVIDER: S-EPMC2697278 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature