A chemogenomics view on protein-ligand spaces.

ABSTRACT:

Background

Chemogenomics is an emerging inter-disciplinary approach to drug discovery that combines traditional ligand-based approaches with biological information on drug targets and lies at the interface of chemistry, biology and informatics. The ultimate goal in chemogenomics is to understand molecular recognition between all possible ligands and all possible drug targets. Protein and ligand space have previously been studied as separate entities, but chemogenomics studies deal with large datasets that cover parts of the joint protein-ligand space. Since drug discovery has traditionally focused on ligand optimization, the chemical space has been studied extensively. The protein space has been studied to some extent, typically for the purpose of classification of proteins into fu

SUBMITTER: Strombergsson H 

PROVIDER: S-EPMC2697636 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature