Lower diffusion in white matter of children with prenatal methamphetamine exposure.

ABSTRACT:

Background

Methamphetamine use is a common problem among women of childbearing age, leading to an increasing number of children with prenatal methamphetamine exposure. Whether microstructural brain changes associated with prenatal methamphetamine exposure can be detected with diffusion tensor imaging (DTI) is unknown.

Method

Twelve-direction DTI was performed in 29 methamphetamine-exposed and 37 unexposed children ages 3-4 years on a 3-T MRI scanner. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were determined in the corpus callosum (genu and splenium) and bilaterally in the frontal and parietal white matter (WM), basal ganglia (caudate, putamen, globus pallidus), and thalamus.

Results

Children with prenatal methamphetamine exposure had lower AD

SUBMITTER: Cloak CC 

PROVIDER: S-EPMC2697962 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature