Abnormal striatal and thalamic dopamine neurotransmission: Genotype-related features of dystonia.

ABSTRACT:

Objective

To determine whether changes in D(2) receptor availability are present in carriers of genetic mutations for primary dystonia.

Methods

Manifesting and nonmanifesting carriers of the DYT1 and DYT6 dystonia mutations were scanned with [(11)C] raclopride (RAC) and PET. Measures of D(2) receptor availability in the caudate nucleus and putamen were determined using an automated region-of-interest approach. Values from mutation carriers and healthy controls were compared using analysis of variance to assess the effects of genotype and phenotype. Additionally, voxel-based whole brain searches were conducted to detect group differences in extrastriatal regions.

Results

Significant reductions in caudate and putamen D(2) receptor availability were evident in both group

SUBMITTER: Carbon M 

PROVIDER: S-EPMC2697963 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature