Differential effects of early weaning for HIV-free survival of children born to HIV-infected mothers by severity of maternal disease.

ABSTRACT:

Background

We previously reported no benefit of early weaning for HIV-free survival of children born to HIV-infected mothers in intent-to-treat analyses. Since early weaning was poorly accepted, we conducted a secondary analysis to investigate whether beneficial effects may have been hidden.

Methods

958 HIV-infected women in Lusaka, Zambia, were randomized to abrupt weaning at 4 months (intervention) or to continued breastfeeding (control). Children were followed to 24 months with regular HIV PCR tests and examinations to determine HIV infection or death. Detailed behavioral data were collected on when all breastfeeding ended. Most participants were recruited before antiretroviral treatment (ART) became available. We compared outcomes among mother-child pairs who weaned earl

SUBMITTER: Kuhn L 

PROVIDER: S-EPMC2698120 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature