Alteration of gene expression signatures of cortical differentiation and wound response in lethal clear cell renal cell carcinomas.

ABSTRACT: Clear cell renal cell carcinoma (ccRCC) is the most common malignancy of the adult kidney and displays heterogeneity in clinical outcomes. Through comprehensive gene expression profiling, we have identified previously a set of transcripts that predict survival following nephrectomy independent of tumor stage, grade, and performance status. These transcripts, designated as the SPC (supervised principal components) gene set, show no apparent biological or genetic features that provide insight into renal carcinogenesis or tumor progression. We explored the relationship of this gene list to a set of genes expressed in different anatomical segments of the normal kidney including the cortex (cortex gene set) and the glomerulus (glomerulus gene set), and a gene set expressed after serum stimulati

SUBMITTER: Zhao H 

PROVIDER: S-EPMC2698218 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature