Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles.

ABSTRACT: We reported the emergence of resistance to medical triazoles of Aspergillus fumigatus isolates from patients with invasive aspergillosis. A dominant resistance mechanism was found, and we hypothesized that azole resistance might develop through azole exposure in the environment rather than in azole-treated patients. We investigated if A. fumigatus isolates resistant to medical triazoles are present in our environment by sampling the hospital indoor environment and soil from the outdoor environment. Antifungal susceptibility, resistance mechanisms, and genetic relatedness were compared with those of azole-resistant clinical isolates collected in a previous study. Itraconazole-resistant A. fumigatus (five isolates) was cultured from the indoor hospital environment as well as from soil obtain

SUBMITTER: Snelders E 

PROVIDER: S-EPMC2698372 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature