Ontology highlight
ABSTRACT:
SUBMITTER: Crawford GE
PROVIDER: S-EPMC2698431 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Nature methods 20060701 7
Mapping DNase I hypersensitive sites is an accurate method of identifying the location of gene regulatory elements, including promoters, enhancers, silencers and locus control regions. Although Southern blots are the traditional method of identifying DNase I hypersensitive sites, the conventional manual method is not readily scalable to studying large chromosomal regions, much less the entire genome. Here we describe DNase-chip, an approach that can rapidly identify DNase I hypersensitive sites ...[more]