Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene.

ABSTRACT: The alternative splicing of pre-mRNAs is a critical mechanism in genomic complexity, disease, and development. Studies of the receptor for advanced glycation end-products (RAGE) indicate that this gene undergoes a variety of splice events in humans. However, no studies have extensively analyzed the tissue distribution in other species or compared evolutionary differences of RAGE isoforms. Because the majority of studies probing RAGE function have been performed in murine models, we therefore performed studies to identify and characterize the splice variants of the murine RAGE gene, and we compared these to human isoforms. Here, using mouse tissues, we identified numerous splice variants including changes in the extracellular domain or the removal of the transmembrane and cytoplasmic domain

SUBMITTER: Kalea AZ 

PROVIDER: S-EPMC2698653 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature