Mortality with upper gastrointestinal bleeding and perforation: effects of time and NSAID use.

ABSTRACT:

Background

Some people who suffer an upper gastrointestinal bleed or perforation die. The mortality rate was estimated at 12% in studies published before 1997, but a systematic survey of more recent data is needed. Better treatment is likely to have reduced mortality. An estimate of mortality is helpful in explaining to patients the risks of therapy, especially with NSAIDs.

Methods

A systematic review of studies published before 1997, and between 1997 and 2008. Any study architecture was acceptable if it reported on cases who died from any cause of upper gastrointestinal bleed or perforation. Analyses were conducted separately for all cases, and those prescribed NSAID or aspirin.

Results

Information was available for 61,067 cases (81% published since 1997) of whom 5,0

SUBMITTER: Straube S 

PROVIDER: S-EPMC2698873 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature