Nature of the protein universe.
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ABSTRACT:
SUBMITTER: Levitt M
PROVIDER: S-EPMC2698892 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Nature of the protein universe.
Proceedings of the National Academy of Sciences of the United States of America 20090618 27
The protein universe is the set of all proteins of all organisms. Here, all currently known sequences are analyzed in terms of families that have single-domain or multidomain architectures and whether they have a known three-dimensional structure. Growth of new single-domain families is very slow: Almost all growth comes from new multidomain architectures that are combinations of domains characterized by approximately 15,000 sequence profiles. Single-domain families are mostly shared by the majo ...[more]
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