Can we apply the Mendelian randomization methodology without considering epigenetic effects?

ABSTRACT:

Introduction

Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks. Similarly, Mendelian randomization studies, which use the IV methodology for analysis and inference in epidemiology, were introduced into the epidemiologist's toolbox only in the last decade.

Analysis

Mendelian randomization studies using instrumental variables (IVs) have the potential to avoid some of the limitations of observational epidemiology (confounding, reverse causality, regression dilution bias) for making causal inferences. Certain limitations of randomized controlled trials, such as problems with generalizability, feasibility and ethics for some exposures, and high costs, also ma

SUBMITTER: Ogbuanu IU 

PROVIDER: S-EPMC2698894 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature