Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.

ABSTRACT:

Background

The Notch signaling pathway is an evolutionary conserved signal transduction pathway involved in embryonic patterning and regulation of cell fates during development and self-renewal. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, involving as well other signal transduction pathways, and implicated in distinct human diseases. Delta-like 1 (Dll1) is one of the known ligands of the Notch receptors. The role of the Notch ligands is less well understood. Loss-of-function of Dll1 leads to embryonic lethality, but reduction of Delta-like 1 protein levels has not been studied in adult stage.

Methodology/principal findings

Here we present the haploinsufficient phenotype of Dll1 and a missense mutant Dll1 allele (Dll1(C4

SUBMITTER: Rubio-Aliaga I 

PROVIDER: S-EPMC2699037 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature