Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice.

ABSTRACT:

Background

In addition to its well-known expression in dorsal telencephalic progenitor cells, where it regulates cell proliferation and identity, the transcription factor Pax6 is expressed in some ventral telencephalic cells, including many postmitotic neurons. Its functions in these cells are unknown.

Results

We generated a new floxed allele of Pax6 and tested the consequences of a highly specific ventral telencephalic depletion of Pax6. We used the Six3A1A2-Cre allele that drives production of Cre recombinase in a specific region of Pax6-expression close to the internal capsule, through which thalamic axons navigate to cerebral cortex. Depletion in this region caused many thalamic axons to take aberrant routes, either failing to turn normally into ventral telencephalon to

SUBMITTER: Simpson TI 

PROVIDER: S-EPMC2699344 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature