Mitochondrial DNA haplogroups influence AIDS progression.

ABSTRACT:

Objective

Mitochondrial function plays a role in both AIDS progression and HAART toxicity; therefore, we sought to determine whether mitochondrial DNA variation revealed novel AIDS restriction genes, particularly as mitochondrial DNA single-nucleotide polymorphisms are known to influence regulation of oxidative phosphorylation, reactive oxygen species production, and apoptosis.

Design

This is a retrospective cohort study.

Methods

We performed an association study of mitochondrial DNA haplogroups among 1833 European American HIV-1 patients from five US cohorts: the Multicenter AIDS Cohort Study, the San Francisco City Clinic Study, Hemophilia Growth and Development Study, the Multicenter Hemophilia Cohort Study, and the AIDS Linked to Intravenous Experiences cohort to

SUBMITTER: Hendrickson SL 

PROVIDER: S-EPMC2699618 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature