Living without Oxygen: Anoxia-Responsive Gene Expression and Regulation.

ABSTRACT: Many species of marine mollusks demonstrate exceptional capacities for long term survival without oxygen. Analysis of gene expression under anoxic conditions, including the subsequent translational responses, allows examination of the functional mechanisms that support and regulate natural anaerobiosis and permit noninjurious transitions between aerobic and anoxic states. Identification of stress-specific gene expression can provide important insights into the metabolic adaptations that are needed for anoxia tolerance, with potential applications to anoxia-intolerant systems. Various methods are available to do this, including high throughput microarray screening and construction and screening of cDNA libraries. Anoxia-responsive genes have been identified in mollusks; some have known func

SUBMITTER: Larade K 

PROVIDER: S-EPMC2699829 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature