Lack of type VIII collagen in mice ameliorates diabetic nephropathy.

ABSTRACT:

Objective

Key features of diabetic nephropathy include the accumulation of extracellular matrix proteins. In recent studies, increased expression of type VIII collagen in the glomeruli and tubulointerstitium of diabetic kidneys has been noted. The objectives of this study were to assess whether type VIII collagen affects the development of diabetic nephropathy and to determine type VIII collagen-dependent pathways in diabetic nephropathy in the mouse model of streptozotocin (STZ)-induced diabetes.

Research design and methods

Diabetes was induced by STZ injections in collagen VIII-deficient or wild-type mice. Functional and histological analyses were performed 40 days after induction of diabetes. Type VIII collagen expression was assessed by Northern blots, immunohistochemist

SUBMITTER: Hopfer U 

PROVIDER: S-EPMC2699847 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature