Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.

ABSTRACT:

Objective

Linkage of the chromosome 1q21-25 region to type 2 diabetes has been demonstrated in multiple ethnic groups. We performed common variant fine-mapping across a 23-Mb interval in a multiethnic sample to search for variants responsible for this linkage signal.

Research design and methods

In all, 5,290 single nucleotide polymorphisms (SNPs) were successfully genotyped in 3,179 type 2 diabetes case and control subjects from eight populations with evidence of 1q linkage. Samples were ascertained using strategies designed to enhance power to detect variants causal for 1q linkage. After imputation, we estimate approximately 80% coverage of common variation across the region (r (2) > 0.8, Europeans). Association signals of interest were evaluated through in silico replicati

SUBMITTER: Prokopenko I 

PROVIDER: S-EPMC2699860 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature