Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.

ABSTRACT:

Objective

KCNQ1 gene polymorphisms are associated with type 2 diabetes. This linkage appears to be mediated by altered beta-cell function. In an attempt to study underlying mechanisms, we examined the effect of four KCNQ1 single nucleotide polymorphisms (SNPs) on insulin secretion upon different stimuli.

Research design and methods

We genotyped 1,578 nondiabetic subjects at increased risk of type 2 diabetes for rs151290, rs2237892, rs2237895, and rs2237897. All participants underwent an oral glucose tolerance test (OGTT); glucagon-like peptide (GLP)-1 and gastric inhibitory peptide secretion was measured in 170 participants. In 519 participants, a hyperinsulinemic-euglycemic clamp was performed, in 314 participants an intravenous glucose tolerance test (IVGTT), and in 102 su

SUBMITTER: Mussig K 

PROVIDER: S-EPMC2699873 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature