Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys.

ABSTRACT:

Objective

Caloric restriction (CR) has been shown to retard aging processes, extend maximal life span, and consistently increase insulin action in experimental animals. The mechanism by which CR enhances insulin action, specifically in higher species, is not precisely known. We sought to examine insulin receptor signaling and transcriptional alterations in skeletal muscle of nonhuman primates subjected to CR over a 4-year period.

Research design and methods

At baseline, 32 male adult cynomolgus monkeys (Macaca fascicularis) were randomized to an ad libitum (AL) diet or to 30% CR. Dietary intake, body weight, and insulin sensitivity were obtained at routine intervals over 4 years. At the end of the study, hyperinsulinemic-euglycemic clamps were performed and skeletal muscle (

SUBMITTER: Wang ZQ 

PROVIDER: S-EPMC2699875 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature