Sex differences in response to nicotine in C57Bl/6:129SvEv mice.

ABSTRACT:

Introduction

Human studies suggest that smoking behavior in men may depend more on the pharmacological effects of nicotine, whereas in women, this behavior may rely more on nonpharmacological factors associated with smoking. Investigation of these parameters in mice may also reveal sex differences.

Methods

Male and female C57Bl/6:129SvEv hybrid mice were exposed to increasing concentrations of nicotine in a voluntary oral nicotine consumption paradigm in which we measured fluid consumption over time and dose. Separate cohorts of mice were exposed to nicotine in a place-conditioning paradigm, and preference was determined. These behavioral models were used to examine sex differences in mice as they rely on pharmacological as well as nonpharmacological factors. Mice exposed to

SUBMITTER: Isiegas C 

PROVIDER: S-EPMC2699930 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature