A randomized, controlled trial of bupropion sustained-release for preventing tobacco relapse in recovering alcoholics.

ABSTRACT:

Introduction

Studies examining the efficacy of tobacco dependence treatment among recovering alcoholic smokers have produced mixed findings. We set out to investigate this issue further by conducting a randomized, double-blind, placebo-controlled trial of bupropion sustained-release (SR) for smoking relapse prevention among abstinent alcoholic smokers.

Methods

Participants (N = 195) met DSM-IV criteria for a history of alcohol abuse or dependence and had at least 1 year of continuous abstinence from alcohol and drugs. Open-label treatment with nicotine patch therapy was provided to all subjects for 8 weeks. The initial nicotine patch dose was determined by the subject's baseline serum cotinine concentration with an aim to achieve 100% cotinine replacement. All subjects who w

SUBMITTER: Hays JT 

PROVIDER: S-EPMC2699931 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature