118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.

ABSTRACT:

Background

Folic acid taken in early pregnancy reduces risks for delivering offspring with several congenital anomalies. The mechanism by which folic acid reduces risk is unknown. Investigations into genetic variation that influences transport and metabolism of folate will help fill this data gap. We focused on 118 SNPs involved in folate transport and metabolism.

Methods

Using data from a California population-based registry, we investigated whether risks of spina bifida or conotruncal heart defects were influenced by 118 single nucleotide polymorphisms (SNPs) associated with the complex folate pathway. This case-control study included 259 infants with spina bifida and a random sample of 359 nonmalformed control infants born during 1983-86 or 1994-95. It also included 214 i

SUBMITTER: Shaw GM 

PROVIDER: S-EPMC2700092 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature