Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer.

ABSTRACT:

Background

Inhibitor of differentiation 4 (Id4), a member of the Id gene family is also a dominant negative regulator of basic helix loop helix (bHLH) transcription factors. Some of the functions of Id4 appear to be unique as compared to its other family members Id1, Id2 and Id3. Loss of Id4 gene expression in many cancers in association with promoter hypermethylation has led to the proposal that Id4 may act as a tumor suppressor. In this study we provide functional evidence that Id4 indeed acts as a tumor suppressor and is part of a cancer associated epigenetic re-programming.

Methods

Data mining was used to demonstrate Id4 expression in prostate cancer. Methylation specific polymerase chain reaction (MSP) analysis was performed to understand molecular mechanisms associated

SUBMITTER: Carey JP 

PROVIDER: S-EPMC2700118 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature