Identification of gene co-regulatory modules and associated cis-elements involved in degenerative heart disease.

ABSTRACT:

Background

Cardiomyopathies, degenerative diseases of cardiac muscle, are among the leading causes of death in the developed world. Microarray studies of cardiomyopathies have identified up to several hundred genes that significantly alter their expression patterns as the disease progresses. However, the regulatory mechanisms driving these changes, in particular the networks of transcription factors involved, remain poorly understood. Our goals are (A) to identify modules of co-regulated genes that undergo similar changes in expression in various types of cardiomyopathies, and (B) to reveal the specific pattern of transcription factor binding sites, cis-elements, in the proximal promoter region of genes comprising such modules.

Methods

We analyzed 149 microarray samples from

SUBMITTER: Danko CG 

PROVIDER: S-EPMC2700136 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature