Targeting of Drosophila rhodopsin requires helix 8 but not the distal C-terminus.

ABSTRACT:

Background

The fundamental role of the light receptor rhodopsin in visual function and photoreceptor cell development has been widely studied. Proper trafficking of rhodopsin to the photoreceptor membrane is of great importance. In human, mutations in rhodopsin involving its intracellular mislocalization, are the most frequent cause of autosomal dominant Retinitis Pigmentosa, a degenerative retinal pathology characterized by progressive blindness. Drosophila is widely used as an animal model in visual and retinal degeneration research. So far, little is known about the requirements for proper rhodopsin targeting in Drosophila.

Methodology/principal findings

Different truncated fly-rhodopsin Rh1 variants were expressed in the eyes of Drosophila and their localization was anal

SUBMITTER: Kock I 

PROVIDER: S-EPMC2700256 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature