Colgate/hdac1 Repression of foxd3 expression is required to permit mitfa-dependent melanogenesis.

ABSTRACT: Neural crest-derived pigment cell development has been used extensively to study cell fate specification, migration, proliferation, survival and differentiation. Many of the genes and regulatory mechanisms required for pigment cell development are conserved across vertebrates. The zebrafish mutant colgate (col)/histone deacetylase1 (hdac1) has reduced numbers, delayed differentiation and decreased migration of neural crest-derived melanophores and their precursors. In hdac1(col) mutants normal numbers of premigratory neural crest cells are induced. Later, while there is only a slight reduction in the number of neural crest cells in hdac1(col) mutants, there is a severe reduction in the number of mitfa-positive melanoblasts suggesting that hdac1 is required for melanoblast specification. Co

SUBMITTER: Ignatius MS 

PROVIDER: S-EPMC2700343 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature