Heparin-binding EGF-like growth factor is a potent dilator of terminal mesenteric arterioles.

ABSTRACT:

Objective

We have previously shown that heparin-binding EGF-like growth factor (HB-EGF) protects the intestines from multiple forms of injury via direct cytoprotective effects on the intestinal mucosa. In this study, we examined the effects of HB-EGF on the hemodynamics of intestinal arterioles, the major resistance vessels that regulate blood flow to the intestines, as an additional mechanism of HB-EGF-mediated intestinal protection.

Methods

The hemodynamic effects of HB-EGF in rodent terminal mesenteric arterioles and human submucosal arterioles were examined ex vivo using a video dimension analyzer. Cultured human intestinal microvascular endothelial cells (HIMEC) were used to elucidate the mechanisms of HB-EGF-induced vasodilation.

Results

HB-EGF significantly inc

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC2700363 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature