Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization.

ABSTRACT:

Background

The correct folding and dimerization of tubulins, before their addition to the microtubular structure, needs a group of conserved proteins called cofactors A to E. The biochemical analysis of cofactors gave an insight to their general functions, however not much is known about the domain structure and detailed, molecular function of these proteins.

Results

Combining modelling and fold prediction tools, we present 3D models of all cofactors, including several previously unannotated domains of cofactors B-E. Apart from the new HEAT and Armadillo domains in cofactor D and an unusual spectrin-like domain in cofactor C, we have identified a new subfamily of ubiquitin-like domains in cofactors B and E. Together, these observations provide a reliable, molecular level mod

SUBMITTER: Grynberg M 

PROVIDER: S-EPMC270062 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature