Total synthesis of phomactin A.

ABSTRACT: A total synthesis of (+/-)-phomactin A is described to highlight the final completion of a complex natural product target that had commenced with an intramolecular oxa-[3 + 3] annulation strategy in the construction of the ABD-tricycle. These efforts reveal structural intricacies of this ABD-tricycle with an illustrative example being the conformational analysis that was ultimately critical for the C5a-homolgation.

SUBMITTER: Tang Y 

PROVIDER: S-EPMC2701356 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature