Cytoplasmic Kaiso is associated with poor prognosis in non-small cell lung cancer.

ABSTRACT:

Background

Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cytoplasmic/nuclear Kaiso in human lung cancer.

Methods

In this study, immunohistochemical studies were performed on 20 cases of normal lung tissues and 294 cases of non-small cell lung cancer (NSCLC), including 50 cases of paired lymph node metastases and 88 cases with complete follow-up records. Three lung cancer cell lines showing primarily nuclear localization of Kaiso were selected to examine whether roles of Kaiso in cytoplasm and in nucleus are identical. N

SUBMITTER: Dai SD 

PROVIDER: S-EPMC2701439 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature