Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients.

ABSTRACT:

Aim

To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients.

Methods

Marker genes were initially identified using DNA microarray data from a rat liver fibrosis model. The expression level of each fibrosis associated marker gene was analyzed using reverse transcription-polymerase chain reaction (RT-PCR) in clinical biopsy specimens from HCV-positive patients (n = 61). Analysis of changes in expression patterns and interactions of marker genes in functional categories was used to assess the biological mechanism of fibrosis.

Results

The profile data showed several biological changes asso

SUBMITTER: Takahara Y 

PROVIDER: S-EPMC2701521 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature