Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.

ABSTRACT: Maintenance of vascular integrity is critical for homeostasis, and temporally and spatially regulated vascular leak is a central feature of inflammation. Sphingosine-1-phosphate (S1P) can regulate endothelial barrier function, but the sources of the S1P that provide this activity in vivo and its importance in modulating different inflammatory responses are unknown. We report here that mutant mice engineered to selectively lack S1P in plasma displayed increased vascular leak and impaired survival after anaphylaxis, administration of platelet-activating factor (PAF) or histamine, and exposure to related inflammatory challenges. Increased leak was associated with increased interendothelial cell gaps in venules and was reversed by transfusion with wild-type erythrocytes (which restored plasma

SUBMITTER: Camerer E 

PROVIDER: S-EPMC2701879 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature