A core-attachment based method to detect protein complexes in PPI networks.

ABSTRACT:

Background

How to detect protein complexes is an important and challenging task in post genomic era. As the increasing amount of protein-protein interaction (PPI) data are available, we are able to identify protein complexes from PPI networks. However, most of current studies detect protein complexes based solely on the observation that dense regions in PPI networks may correspond to protein complexes, but fail to consider the inherent organization within protein complexes.

Results

To provide insights into the organization of protein complexes, this paper presents a novel core-attachment based method (COACH) which detects protein complexes in two stages. It first detects protein-complex cores as the "hearts" of protein complexes and then includes attachments into these cores

SUBMITTER: Wu M 

PROVIDER: S-EPMC2701950 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature