AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin.

ABSTRACT:

Background

AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed in diverse tissues. Recent papers showed that during angiogenesis, AQP1 is expressed preferentially by microvessels, favoring angiogenesis via the increase of permeability In particular, in AQP1 null mice, endothelial cell migration is impaired without altering their proliferation or adhesion. Therefore, AQP1 has been proposed as a novel promoter of tumor angiogenesis.

Methods/findings

Using targeted silencing of AQP1 gene expression, an impairment in the organization of F-actin and a reduced migration capacity was demonstrated in human endothelial and melanoma cell lines. Interestingly, we showed, for the first time, that AQP1 co-immunoprecipitated with Lin-7. Lin7-GFP experime

SUBMITTER: Monzani E 

PROVIDER: S-EPMC2701997 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature