Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.

ABSTRACT:

Background

Breast cancer cell lines have been used widely to investigate breast cancer pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it is important to understand how well and which cell lines best model that diversity. In particular, microarray studies have identified molecular subtypes-luminal A, luminal B, ERBB2-associated, basal-like and normal-like-with characteristic gene-expression patterns and underlying DNA copy number alterations (CNAs). Here, we studied a collection of breast cancer cell lines to catalog molecular profiles and to assess their relation to breast cancer subtypes.

Methods

Whole-genome DNA microarrays were used to profile gene expression and CNAs in a collection of 52 widely-used breast cancer cell lines, an

SUBMITTER: Kao J 

PROVIDER: S-EPMC2702084 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature