Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility.

ABSTRACT:

Background

Contamination of the uterine lumen with bacteria is ubiquitous in cattle after parturition. Some animals develop endometritis and have reduced fertility but others have no uterine disease and readily conceive. The present study tested the hypothesis that postpartum cattle that develop persistent endometritis and infertility are unable to limit the inflammatory response to uterine bacterial infection.

Methods

Endometrial biopsies were collected several times during the postpartum period from animals that were subsequently infertile with persistent endometritis (n = 4) or had no clinical disease and conceived to first insemination (n = 4). Quantitative PCR was used to determine the expression of candidate genes in the endometrial biopsies, including the Toll-like re

SUBMITTER: Herath S 

PROVIDER: S-EPMC2702306 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature