Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues.

ABSTRACT: Caloric restriction has been extensively investigated as an intervention that both extends lifespan and delays age-related disease in mammals. In mice, much interest has centered on evaluating gene expression changes induced by caloric restriction (CR) in particular tissue types, but the overall systemic effect of CR among multiple tissues has been examined less extensively. This study presents a comparative analysis of microarray datasets that have collectively examined the effects of CR in 10 different tissue types (liver, heart, muscle, hypothalamus, hippocampus, white adipose tissue, colon, kidney, lung and cochlea). Using novel methods for comparative analysis of microarray data, detailed comparisons of the effects of CR among tissues are provided, and 28 genes for which expression re

SUBMITTER: Swindell WR 

PROVIDER: S-EPMC2702675 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature