Evidence for the concerted evolution between short linear protein motifs and their flanking regions.

ABSTRACT:

Background

Linear motifs are short modules of protein sequences that play a crucial role in mediating and regulating many protein-protein interactions. The function of linear motifs strongly depends on the context, e.g. functional instances mainly occur inside flexible regions that are accessible for interaction. Sometimes linear motifs appear as isolated islands of conservation in multiple sequence alignments. However, they also occur in larger blocks of sequence conservation, suggesting an active role for the neighbouring amino acids.

Results

The evolution of regions flanking 116 functional linear motif instances was studied. The conservation of the amino acid sequence and order/disorder tendency of those regions was related to presence/absence of the instance. For the maj

SUBMITTER: Chica C 

PROVIDER: S-EPMC2702822 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature