Identification of Ind transcription activation and repression domains required for dorsoventral patterning of the CNS.

ABSTRACT: Specification of cell fates across the dorsoventral axis of the central nervous system in Drosophila involves the subdivision of the neuroectoderm into three domains that give rise to three columns of neural precursor cells called neuroblasts. Ventral nervous system defective (Vnd), intermediate neuroblasts defective (Ind) and muscle segment homeobox (Msh) are expressed in the three columns from ventral to dorsal, respectively. The products of these genes play multiple important roles in formation and specification of the embryonic nervous system. Ind, for example, is known to play roles in two important processes. First, Ind is essential for formation of neuroblasts conjunction with SoxB class transcription factors. Sox class transcription factors are known to specify neural stem cells in

SUBMITTER: Von Ohlen TL 

PROVIDER: S-EPMC2703006 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature