Intestinal cytokine mRNA expression in canine inflammatory bowel disease: a meta-analysis with critical appraisal.

ABSTRACT: Data implicating mucosal cytokines in the pathogenesis of canine inflammatory bowel disease (IBD) are limited. The aims of the present study were to report new findings of intestinal cytokine expression in dogs with IBD and to compare these data with previous studies through meta-analysis. Cytokine mRNA abundance in intestinal biopsies collected prospectively was evaluated by using a semiquantitative RT-PCR technique. For meta-analysis, an electronic database search revealed 3 clinical trials, all of which were nonrandomized (type III) case series. Prospective analysis showed that the intestines of healthy dogs and those with IBD express numerous cytokines and that a proinflammatory expression profile is not a feature of small or large-intestinal IBD. The meta-analysis data included 158 do

SUBMITTER: Jergens AE 

PROVIDER: S-EPMC2703145 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature