Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.

ABSTRACT: Ovarian hyperstimulation syndrome is a frequent complication occurring during in vitro fertilization cycles. It is characterized by a massive ovarian enlargement associated with an accumulation of extra vascular fluid. Here we show that liver X receptor (LXR)-alpha and LXR-beta deficient mice present many clinical and biological signs of ovarian hyperstimulation syndrome: ovarian enlargement, hemorrhagic corpora lutea, increased ovarian vascular permeability, and elevated estradiol. Ovulation stimulation resulted in excessive ovarian response to exogenous gonadotropins because follicle number and estradiol production were higher in transgenic mice. LXR deficiency also leads to perturbations in general inflammatory status, associated with ovarian il-6 deregulation. Upon treatment with the s

SUBMITTER: Mouzat K 

PROVIDER: S-EPMC2703512 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature