Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor.

ABSTRACT: Prolactin (PRL) affects the development and function of the reproductive system by binding to two types of receptors, which differ by the size of their intracellular domain in rodents. Whereas the signaling pathway through the long form of the receptor (PRL-RL) is well characterized, signaling through the short form (PRL-RS) remains obscure. In this investigation, we examined transcription factors regulated by PRL in the ovary and decidua of mice expressing only PRL-RS in a PRL receptor null background. These mice provide a powerful in vivo model to study the selective signaling mechanism of PRL through PRL-RS independent of PRL-RL. We also examined the regulation of transcription factors in ovarian and uterine cell lines stably transfected with PRL-RS or PRL-RL. We focused our investigati

SUBMITTER: Devi YS 

PROVIDER: S-EPMC2703532 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature